Becoming a grandparent and its effect on well-being: the role of order of transitions, time, and gender

Objectives Although the majority of older people are grandparents, little is known on whether and how the transition into grandparenthood affects their well-being. Moreover, evidence on whether the order of the transition, the time since grandchild’s birth, and the socio-demographic characteristics of the offspring modify the grandparental well-being is scarce. Taking into account these factors, our study examines the association between becoming a grandparent and subsequent well-being. Methods Our study is based on grandparents aged 50 and over from waves 4-6 of the Survey of Health, Ageing and Retirement in Europe. Using longitudinal analyses, we investigate associations between becoming a grandparent and subsequent life satisfaction, positive affect, and depression controlling for demographic and socio-economic factors as well as health and well-being at baseline. Furthermore, we explore the role of modifying factors such as whether the grandchild was first-born, the time since transition, and socio-demographic characteristics of the offspring who became a parent. Results Becoming a grandparent has a positive effect on well-being only among women who became grandmothers for the first time and via their daughters. Moreover, this effect is particularly strong in the proximity of the birth of the grandchild. No effects were found among first-time grandfathers. Having an additional grandchild does not affect well-being of grandparents, regardless of the offspring’s characteristics

PIV measurements over a double bladed Darrieus-type vertical axis wind turbine: A validation benchmark

Vertical axis wind turbines (VAWTs) are very attractive for in-home power generation since they can be adopted even at low wind speeds and highly variable wind direction. Even if significant experimental research activity has been carried out to improve VAWTs performance, the ability to accurately reproduce flow field characteristics around turbine blades by CFD (computational fluid dynamics) techniques represents a powerful approach to further enhance wind turbines performance. Thanks to CFD, in fact, it is possible to reproduce flow characteristics with a detail level impossible to achieve by experiments. Nevertheless, in order to appropriately analyze the flow structure by CFD application, an accurate validation is essential, and high-quality measurements of some main flow characteristics are required. In recent publications the authors investigated, both experimentally and numerically, the performance of an innovative double bladed Darrieus-type VAWT, with the aim to define an optimal configuration also focusing on self-starting ability of the prototype by employing CFD technique. Nevertheless, comparison between experiments and numerical results was made only in terms of power and torque coefficient. To overcome such limitation, in this paper the authors propose an experimental benchmark case for CFD results validation, describing detailed flow field in correspondence of one pair of blades of the innovative Darrieus-type VAWT in static conditions. Measurements were performed employing Particle Image Velocimetry (PIV) technique on a scaled model of the turbine blades realized by 3D printing. An uncertainty analysis was also performed which showed a high accuracy of the obtained experimental results. The measurements of the main flow characteristics (bi-dimensional velocity components) were then used for a test case CFD validation of two different turbulence model

Influence of Installation Conditions on Heating Bodies Thermal Output: Preliminary Experimental Results☆

Abstract Heating bodies are thermodynamic systems whose heat output is strongly dependent on boundary conditions and in about a century several attempts have been made for its experimental determination. To this aim, at the beginning of 60s, in Europe different national standards were adopted (e.g. in 1967 in Italy the UNI 6514/1967). At European level, the EN 442-1:2014 and EN 442-2:2014 allows the heating body heat output estimation with an expanded uncertainty lower than 1% and they are now accepted in various international markets. The EN 442 also allows heat output calculation in operating conditions different from standard ones by employing theoretical-experimental correlations that, by their nature, are not able to include any possible actual operating condition. In fact, in actual operating conditions the heating body heat output depends on several factors, among which: i) installation position with respect to the wall and the floor; ii) presence grid/shelf/niche or an obstruction caused by curtains on the heating body; iii) thermo-fluid-dynamic condition variations (inlet flow rate and temperature); iv) hydraulic connections. Radiators represent the most spread heating body (installed since the end of '800) and in the last decades different radiators typologies have been proposed on the market, characterized by different materials, sizes, shapes, etc. In the present paper the authors present the preliminary result of an experimental campaign on field for the heat output measurement of different radiators typologies (cast iron, aluminum) as a function of different installation and operating conditions. The influence on the heating body performance and the associate technical-economical consequences in terms of heat cost allocation accuracy have been investigated

Multiple metachronus proliferative fasciitis occurring in different anatomic regions: a case report and review of the literature.

Proliferative fasciitis is a benign lesion that usually has a self-limited course and rarely recurs after excision. In the literature, the multifocal occurrence of PF in different anatomic sites has not been reported so far. In this report, we describe the clinical case of a 30-year-old woman with two metachronous proliferative fasciitis occurring firstly in the orbit and, after 18 months, in the forearm; we also review the available literature on this topic, outlining guidelines for therapy and the follow-up of these patients

Emetogenicity of Antibody-Drug Conjugates (ADCs) in Solid Tumors with a Focus on Trastuzumab Deruxtecan: Insights from an Italian Expert Panel

In the past decade, nine antibody-drug conjugates (ADCs) have been approved for the treatment of various tumors, four of which specifically for solid malignancies. ADCs deliver the cytotoxic payload to the cancer site, thereby improving chemotherapy efficacy while reducing systemic drug exposure and toxicity. With their high selectivity, ADCs are associated with a manageable side-effect profile, with nausea and vomiting being among the most frequent toxicities, although this may vary according to the respective ADC and the associated payload. Information about the emetic risk of the new ADC compounds is limited. Three virtual focus groups of Italian oncologists were held to raise awareness on the importance of an antiemetic prophylaxis regimen to prevent and mitigate ADC-associated emesis and its sequelae. After reviewing published evidence and guidelines, the three expert panels shared their experience on the early use of ADCs gained through the participation in specific clinical trials and their clinical practice. The following issues were discussed: antiemetic therapy during trastuzumab deruxtecan treatment, with a protocol adopted at the San Raffaele Hospital (Milan, Italy); the use of steroids; the management of anticipatory nausea during trastuzumab deruxtecan therapy; nutritional counselling; and effective doctor\u2013patient communication. The experts acknowledged that recommendations should be drug-specific, and formulated opinion-based advice intended to guide physicians in their daily practice until further evidence emerges

Health-related quality of life in breast cancer patients treated with CDK4/6 inhibitors: a systematic review

Background: Evaluation of health-related quality of life (HR-QoL) among cancer patients has gained an increasing importance and is now a key determinant of anticancer treatments’ value. HR-QoL has been assessed in trials testing cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in breast cancer (BC), using various questionnaires at different timepoints. HR-QoL reports from BC patients treated with CDK4/6i in the real-world setting are also available. Methods: We systematically reviewed the literature, searching for full-length articles, and selected conference abstracts reporting data on HR-QoL in BC patients at any stage and of any molecular subtype treated with abemaciclib, palbociclib or ribociclib. Results: A total of 533 full-length articles and 143 abstracts were retrieved. After screening for eligibility, 38 records were included (31 clinical trials; 7 real-world reports). Assessment methods were heterogeneous across studies in terms of questionnaires, evaluation timepoints and endpoints. Overall, adding CDK4/6i to endocrine therapy did not worsen patients’ HR-QoL, with a positive trend towards pain improvement. Gastrointestinal scores (diarrhea, nausea and appetite loss) statistically favored the control arm among metastatic BC patients receiving abemaciclib, whereas they were superimposable in the early setting. The combination of palbociclib and endocrine therapy showed similar HR-QoL outcomes compared with endocrine therapy alone, but determined better scores compared with chemotherapy. HR-QoL was specifically assessed in premenopausal patients treated with ribociclib, showing similar scores compared with postmenopausal patients. Conclusions: Despite methodological heterogeneity does not allow a proper comparison, HR-QoL was generally maintained with CDK4/6i. However, differences between abemaciclib, palbociclib and ribociclib exist and mainly rely on the distinct safety profiles of the compounds. These differences should be acknowledged and taken into account in the clinical practice

Numerical and Experimental Investigation of the Flow over a Car Prototype for the Shell Eco Marathon

The Eco-Marathon is a challenge organized by Shell in which student teams compete in designing energy-efficient vehicles. The event spark debate about the future of mobility and inspire engineers to push the boundaries of fuel efficiency. The aim of the present work consists of the numerical and experimental investigation of the aerodynamic performance of a Shell Eco Marathon prototype designed by a group of students of the University of Cassino, Italy. The car design has been provided by means of detailed 3D CFD modelling with Comsol Multiphysics®. The numerical tool has been validated against experiments conducted at the Laboratory of Industrial Measurements (LaMI) of the University of Cassino. In particular, a scale model of the car has been investigated in an open chamber wind tunnel by means of the Particle Image Velocimetry (PIV) technique, for different free stream velocities within the range 11 – 23 m/s. Measurements have been associated to a proper uncertainty analysis. The experimental data has been compared to numerical results obtained employing different turbulence models and the validated numerical tool has been applied to the simulation of the full-scale car model, allowing to analyse the wake flow structures, and estimate the overall drag coefficient